Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.

Among the identified brain regions with increased activation in the Evening start group (in Study 1), superior temporal gyrus was previously shown to have a positive trend of activation in response to facial expressions with increasing intensity of fear among healthy controls (but not schizophrenic patients) ( Radua et al., 2010 ).

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While in Study 2, the Morning start group showed increased activation compared to the Varying start group at a nominally significant level in regions with pain (right precentral gyrus, right supplementary motor area) and sensory processing (bilateral paracentral lobule) functions.

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