Long-term kidney function in children with Wilms tumour and constitutional WT1 pathogenic variant.

We observed variation in the frequency of bilateral tumours by pathogenic variant type, 7/8 patients carrying nonsense pathogenic variants compared with frameshift (3/7), splice site (2/4), deletions (1/4), and missense (0/2), but this did not reach statistical significance (p = 0.192; Tables 1 and 2 ).

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