nominally significantp < 0.05
Examining the 453 nominally significant ( p < 0.05) upregulated trans-eGenes, we found that they were significantly enriched for multiple pathways critical to mucin production and secretion, including IRE1-mediated unfolded protein response , protein N-linked glycosylation , and ER to Golgi vesicle mediated transport , Golgi subcompartment , as well as in marker genes of mucus secretory cells determined from single cell RNA-sequencing (scRNA-seq) data 30 (Fig. 4e , Supplementary Data 7 ).