The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study.

Front Endocrinol (Lausanne) · 2022 · PMC8962375 · PMID 35360055

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a negative trendno p-value reported

As we were not expecting to see a negative trend in the association in the OC users, this highlights the question whether the 5-HT4R setting may differ qualitatively, i.e., whether the mechanisms behind a lower 5-HT4R level differ.

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borderline significantno p-value reported

Whereas we found no difference in 5-HT4R binding level at baseline between the groups, we observed a crossover interaction between the OC users and the non-users in the association between baseline 5-HT4R BP ND and treatment response, but notably, the association within each group was only borderline significant, which may be due to power issues.

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