did not reach statistical significancep = 8.9 × 10 –10
highly significantp = 8.9 × 10 –10
Although these variants did not reach statistical significance individually, the results were highly significant when they were combined (OR = 3.72; 95% CI = 2.38–5.82; p = 8.9 × 10 –10 ) ( Vallet et al., 2015 ). 22 distinct variants were recently identified in a Belgian population.