Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations.

6A ) and were borderline significant for OS (HR = 0.24, 95% CI = 0.059–1, p = 0.05; Fig. 6B ).

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5A ), although this just failed to reach significance (HR = 0.56, 95% CI = 0.31–1.02, p = 0.057), and significantly improved OS (Fig. 5A ) (HR = 0.4, 95% CI = 0.18–0.85, p = 0.02).

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After separating into three clusters, the “immune-hot” cluster of patients with the highest infiltration of T-cell subtypes showed improved disease-free survival (DFS) and overall survival (OS) compared to the other two groups that had lower T-cell levels; however, this did not reach statistical significance (Supplementary Fig. 6B ).

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In this “hot-spot” analysis, high CD4 levels also correlated with better prognosis but with borderline significance, while no other single or multiplex marker had prognostic significance (Supplementary Fig. 9 ).

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