Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis.

Focusing on myelinated fibres, we identified TDP-43 accumulation in a higher proportion of ALS compared with non-ALS patients, a difference that, however, did not reach statistical significance: in ALS patients we identified TDP-43 accumulation in Schwann cells cytoplasm in 38 cases (66.7%) and in the axon in 26 ALS samples (45.6%), while in non-ALS patients TDP-43 accumulation was detected in Schwann cells cytoplasm in eight cases (34.8%) and in the axon in five samples (21.7%) ( Supplementary Tables 1, 2 and 4 ).

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