Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways.

Arch Pharm Res · 2022 · PMC8967791 · PMID 35244883

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did not reach statistical significancep > 0.05actually significant

Treatment with DCN 4 h before acetaminophen reduced hepatic expression of CYP2E1 mRNA by 19.62% and treatment 2 h after acetaminophen by 14.59%, but these decreases did not reach statistical significance (p > 0.05) compared to the acetaminophen group (Fig. 7 ).

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