In the same way, data from the COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Arterial Hypertension) and other registry reports showed a significant trend towards an increased age and a higher percentage of cardiovascular comorbidities at diagnosis of PAH, together with a weaker response to targeted PAH therapy[ 6 , 7 ].
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Treatment with neurohormonal inhibitors and prognostic outcome in pulmonary arterial hypertension with risk factors for left heart disease.
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