Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.

We also identified a trend towards reduced total CD3 + T cells that did not reach statistical significance but found significant differences in the relative populations of CD4 + and CD8 + expressing T cell subsets with a higher CD4 to CD8 ratio in TBRS compared to unaffected individuals (Figure 3C; Online Supplementary Figure 2C ).

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