APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia.

Alzheimers Res Ther · 2022 · PMC8969347 · PMID 35354468

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hedged sentences

0.2210

closest p · 4.4× alpha

0.2210

boldest claim

The sentences

a positive trendp =0.221not close (p > 0.1)

A positive trend was found for ε4 heterozygosity in both crude ( β 0.67, p =0.221) and adjusted ( β 0.41, p =0.471) analyses, although neither reached statistical significance (see Table 5 ).

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showed a trendno p-value reported

AD pathology within the suprachiasmatic nuclei and the ventrolateral preoptic area has also been implicated in sleep disturbance [ 52 , 53 ] with hippocampal Aβ burden in otherwise healthy adults correlating significantly with impairments in non-random eye movement (NREM) slow wave activity generation and showed a trend towards deterioration in macro-architectural sleep parameters [ 54 ].

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