Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats.

Front Physiol · 2022 · PMC8979289 · PMID 35388287

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may not be significantno p-value reported

However, unchanged biliary secretion of bile acids between Mrp2-deficient groups suggests that the contribution of Abcg2 to observed changes in BA metabolomics may not be significant.

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did not reach statistical significanceno p-value reported

Mrp2 deficiency increased hepatocellular injury as evident by increased plasma alanine aminotransferase (ALT) activity, though increase in aspartate aminotransferase (AST) did not reach statistical significance ( Figures 1D , E ).

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