Blood-Based miRNA Biomarkers as Correlates of Brain-Based miRNA Expression.

Front Mol Neurosci · 2022 · PMC8981579 · PMID 35392269

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highly significantP < 2.2 × 10 –16actually significant

When miRNA expression levels were averaged for tissue type across animals within the groups, Spearman’s rank correlations between PBMCs and the brain regions are all highly significant ( r s = 0.47–0.57; P < 2.2 × 10 –16 ), although pairwise correlations among the brain regions are markedly stronger ( r s = 0.86–0.99).

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nominally significantP < 0.05actually significant

Nominally significant pairwise correlations (one-sided P < 0.05) between peripheral blood and mean brain expression levels of individual miRNAs were observed for 39 and 44 miRNAs in each group.

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