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HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities.

Clin Transl Med · 2022 · PMC8982313 · PMID 35384333

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Surprisingly, BsAb completely abolished HCC1954 tumour growth in NCG mice reconstructed with human peripheral blood mononuclear cells (PBMCs) (Figure 3D,E ), while mAbs and combination treatments alone only slightly suppressed tumour growth and failed to reach statistical significance.

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