Furthermore, genes regulating glutathione metabolism (e.g., Gclc , Gsr , Gss ) were largely unaltered although GPX3 expression showed a trend toward increase in both Cre+;Bscl2 w/w and Bscl2 cKO hearts compared with Ctrl hearts (Figure S4(D) ).
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BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism.
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