The well-characterized miR-155 target gene INPP5D (encoding SHIP-1) was downregulated in all five donors although this did not reach statistical significance ( Supplementary Figure 5C ).
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miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation.
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