Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma.

While correlation with BM infiltration in paired plasma samples showed a trend toward positive correlation ( Figure 3B , Spearman 0.39 (95%CI −0.2 to 0.77), P=0.171), this comparison did not reach significance, most likely due to two outlier patients (Pt01V, Pt02V) with high tumor burden measured in cfDNA but low BM infiltration ( Figure 3C ).

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