The Botanical Drug PBI-05204, a Supercritical CO₂ Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma.

While RT showed a trend of increased invasion and migration of U87MG and A172 cells compared to that of control cells, PBI-05204 alone or in combination with RT led to more than a 50% reduction of both cell migration and invasion compared to vehicle control or RT only treated cells ( Figures 3A,B ), combination of RT and PBI-05204 showed stronger reduction than PBI-05204 alone.

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