SEOM-SOGUG clinical guideline for localized muscle invasive and advanced bladder cancer (2021).

Clin Transl Oncol · 2022 · PMC8986688 · PMID 35347572

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showed a trendno p-value reported

Adding taxanes to gemcitabine and platinum showed a trend for improved OS but a higher grade ≥ 3 neurotoxicity [ 50 ].

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a numerical trendno p-value reported

Another retrospective analysis from NCDB including 2187 patients with pT3/4 or LN-positive variant histology disease, failed to demonstrate an OS benefit of adjuvant chemotherapy in patients with non-pure UC, although a numerical trend towards improved survival was seen in neuroendocrine tumors and micropapillary differentiation [ 65 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.