The gain in free energy (ΔΔG) of the mutant spike -NTL-125 complexes over that of the mutant spike -hACE2 complexes in most of the studied cases are quite significant and over 1 kcal/mole ( Table 2 ) except for spike mutant number 2, 8 and 9.
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A novel plant lectin, NTL-125, interferes with SARS-CoV-2 interaction with hACE2.
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