Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells.

p53 was also mildly increased in CUG exp+ cells, although the increase did not reach statistical significance ( p = 0.33, Figure 3B ). p21 and p16 are sufficient to establish cell cycle arrest in an independent and interdependent manner ( McHugh and Gil, 2018 ; Di Micco et al., 2021 ).

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