Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood.

In contrast, unlike Bax −/− ;Bak −/− ;Bok −/− foetuses, Bax −/− ;Bak −/− ;Bok −/− ;Casp8 −/− ;Mlkl −/− foetuses did not show external facial clefts, exencephaly or omphalocele, although the differences in the incidence of these defects did not reach statistical significance at the number of animals available (Fig. 2c ).

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