The high densities of TILs, high ratios of PD-1+/CD8+ cells, and high levels of PD-L1 have been suggested that are negatively associated with melanoma brain metastases size, and high levels of PD-L1 may support a marked trend towards better survival [ 33 ].
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Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons.
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