Blood long non-coding RNA intersectin 1-2 is highly expressed and links with increased Th17 cells, inflammation, multiple organ dysfunction, and mortality risk in sepsis patients.

Moreover, it was observed that lnc‐ITSN1‐2 ( Z = −1.852, p = 0.064) had an increasing trend in deaths compared to survivors, but did not reach statistical significance (Figure 4A ); meanwhile, the Th1 cells ( Z = −2.450, p = 0.014), Th17 cells ( Z = −2.124, p = 0.034) and IL‐17A level ( Z = −2.393, p = 0.017) were enhanced in deaths than those in survivors, but not IFN‐γ level ( Z = −1.049, p = 0.294) (Figure 4B‐E ).

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Besides, lnc‐ITSN1‐2 had an increasing trend, but no statistical difference, in septic deaths compared to survivors ( Z = −1.852, p = 0.064).

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