Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices.

Commun Biol · 2022 · PMC8993814 · PMID 35396540

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0620

boldest claim

The sentences

a marginal trend toward significanceP = 0.052so close (0.05 < p ≤ 0.1)

While the main effect of 5- HTT in women showed a marginal trend toward significance ( P = 0.052), with a medium effect size, the planned pairwise comparison indicated that women with 5- HTT- SS tended to have a higher angry MMN amplitude than women with 5- HTT- LL/LS (3.084 ± 0.424 μV, 1.788 ± 0.501 μV, P = 0.052, respectively).

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a marked trendP = 0.062so close (0.05 < p ≤ 0.1)

The four-way mixed ANOVA, comprising gender (male or female) as the between-subjects factor, and the deviant type (fearful or angry), coronal site (left, midline, right) and anterior-posterior site (frontal or central) as the within-subjects factors, revealed a main effect of coronal site (left, midline, right) [ F 2,276 = 7.09, P = .001, ηp 2 = 0.049, (1-β) ≈ 100%] as well as a marked trend of deviant type (fearful vs. angry) [ F 1,138 = 3.53, P = 0.062, ηp 2 = 0.025 (1-β) = 96.43%].

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appeared to be marginally significantP = 0.062so close (0.05 < p ≤ 0.1)

While midline (2.45 ± 0.22 μV, P < 0.001) and right site electrodes (2.05 ± 0.21 μV) showed significant larger MMN amplitudes than the left electrodes (2.35 ± 0.22 μV), fearful MMN (2.47 ± 0.24 μV) showed higher amplitudes than angry MMN (2.09 ± 0.21 μV) that appeared to be marginally significant ( P = 0.062).

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