Long-term high-dose L-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial.

Moreover, a relatively small sample size of the subgroup of patients with severe vasculogenic ED might have prevented to capture slightly significant improvements in PSV at dynamic PDU upon l -ARG supplementation, particularly in patients with borderline scores indicating severity, therefore making it challenging to provide conclusive information concerning the potential effect of l -ARG supplementation in patients with borderline severe vasculogenic ED.

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