showed a trendp = 0.09
1.4 months, HR 0.37, one-sided p < 0.0001) and updated analysis showed a trend towards better median OS in the experimental arm (10.3 vs. 7.5 months, HR 0.79, p = 0.09), which may have been impacted by crossover from the placebo to treatment group [ 10 , 38 ].