Neoadjuvant Treatment Strategies for Resectable Proximal Gastric, Gastroesophageal Junction and Distal Esophageal Cancer.

FLOT)) and found a nonsignificant trend towards improved progression free survival (PFS) with the triplet FLOT regimen [ 36 ].

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In summary, the first two trials approached significance demonstrating the benefit in adding neoadjuvant chemoradiation after induction chemotherapy compared to the same induction chemotherapy regimen [ 43 , 46 ].

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The OEO2 trial evaluated both AC and SCC ( n = 247) patients with cisplatin + 5-FU with significant differences in OS across the entire study, although the SCC subgroup failed to reach significance (HR 0.81, 95% CI 0.61–1.07) [ 23 ].

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