Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment.

[ 19 ] found low DDR gene expression to indicate favourable prognosis in a combined cohort of low-grade glioma (LGG) and glioblastoma patients; however, consistent with our findings here, no survival difference was apparent in glioblastoma patients alone.

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There appeared to be variability between cell lines and treatments ( Figure S3 ); however, an overall trend across cell lines was the predominant upregulation of genes within 24 h after treatment, especially in RT- and TMZ + RT-treated cells ( Figure 5 A).

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