Increased Frequency of CD4⁺ Follicular Helper T and CD8⁺ Follicular T Cells in Human Lymph Node Biopsies during the Earliest Stages of Rheumatoid Arthritis.

Consistent with previous findings [ 29 ], the frequency of CD19 + B cells was increased in early RA patients when compared with healthy controls ( p < 0.05) and showed an elevated trend in RA-risk individuals when compared to healthy controls ( Figure 3 A).

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Similar findings were observed for CD8 + CXCR5 + Tfh cells but did not reach statistical significance ( Figure 2 D).

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