Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation.

A significant trend towards a decreased surface expression in EHT1864-treated CRP-stimulated platelets was also observed for GPV ( Figure 2 (Aiv)) while the surface abundance of GPIbα ( Figure 2 (Av)), integrin β3-subunit ( Figure 2 (Avi)), and CLEC-2 ( Figure 2 (Avii)) were not affected by EHT1864.

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The quantitative cluster analysis ( Figure 1 (Bi–iv)) showed a decreasing trend in the number of detections, cluster density and cluster area on the EHT1864-treated platelets, but this did not reach significance.

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