shRNAs Targeting a Common <i>KCNQ1</i> Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele.

In such a situation, a reduction in repolarizing currents can further depolarize the resting membrane potential, as has been found for rapid delayed rectifier potassium current (I Kr ) reduction [ 40 ] and I Ks blockade by 10 μM chromanol 293B [ 41 ], although the latter did not reach statistical significance due to the low number of cells measured.

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