Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.

Also, 53BP1 expression was significantly downregulated over time in BRCA1 mut -FTE organoid cultures, and ATM and ATR kinases showed a trend toward downregulation ( Figure 5C ), suggesting that the functional loss or deregulation of these key proteins involved in the DDR may contribute to the progression of neoplastic transformation in BRCA1 mut -FTE organoids.

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