Fludarabine exposure predicts outcome after CD19 CAR T-cell therapy in children and young adults with acute leukemia.

However, the mean AUC of CAR T-cell numbers was 1609 (range, 58-3345) in the group with a fludarabine AUC T0−∞ >14, which showed a trend toward a higher AUC of CAR T cells compared with the underexposed group, where a mean AUC of 672 (range, 2-2570) was observed ( P = .07) ( Figure 3A ).

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