a significant trendp < 0.05
The existence of a significant trend was considered when the slope (β) of the model was found to be different from zero and a p -value less than or equal to 0.05 ( p < 0.05).
The existence of a significant trend was considered when the slope (β) of the model was found to be different from zero and a p -value less than or equal to 0.05 ( p < 0.05).
However, it is worth noting that there has been an observed trend of declining applieddoses of vaccines in Brazil over the past 2 decades [ 8 ], especially those immunobiologicals recommended during early childhood [ 27 , 28 ].
This change in trend can be explained by the flexibility of social distancing measures that were initially adopted [ 36 ], which favored the circulation of people and an increase in demand for immunization services [ 11 ], resulting in an increasing trend of the number of applied doses of the HPV vaccine throughout the country.