Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival.

BMC Cancer · 2022 · PMC9008925 · PMID 35421941

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did not reach statistical significanceno p-value reported

In addition, an increasing promoter CpG dinucleotide methylation frequency was observed in case of SOCS1 gene in accelerated and blastic phases of the CML disease than chronic phase but the differences did not reach statistical significance.

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