The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome.

The 48 proteins consistently enriched in plaques in both EOAD and DS also showed a highly significant degree of protein–protein interaction ( p < 1.0 × 10 –16 ; Fig. 3 D) and were almost exclusively classified as either vesicle (enrichment FDR: 4.32 × 10 −9 ) or extracellular proteins (enrichment FDR: 3.34 × 10 −8 ).

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Arl8a, the other paralog of arl8 in vertebrates, was also enriched in amyloid plaques in DS and showed a strong trend for enrichment in plaques in EOAD.

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