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Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women.

J Clin Endocrinol Metab · 2022 · PMC9016453 · PMID 34935937

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In a recent MR study, using partly invalid genetic instruments derived from a modestly powered GWAS meta-analysis ( 24 ) and a preliminary data set that used only about 50% of the UK Biobank women for the eBMD outcome, the causal association between circulating DHEAS and eBMD in women did not reach statistical significance ( 23 ).

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