Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial.

Although only 7% of patients (43/659) received the cisplatin plus 5-fluorouracil regimen because of the covid-19 pandemic and late enrolment of western populations, this regimen also showed a trend for survival benefit (hazard ratio for overall survival 0.31, 95% confidence interval 0.08 to 1.20, P=0.07).

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