Carbonic anhydrase XII inhibition overcomes P-glycoprotein-mediated drug resistance: a potential new combination therapy in cancer.

Cancer Drug Resist · 2021 · PMC9019264 · PMID 35582034

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a strong trendno p-value reported

However, while subsequent studies attributed the high expression of CA IX in renal cancer to mutations in the VHL gene, CA XII expression only exhibited a strong trend and not an unequivocal relationship with VHL mutation status [ 27 ] .

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