<i>Tle4z1</i> Facilitate the Male Sexual Differentiation of Chicken Embryos.

Front Physiol · 2022 · PMC9022655 · PMID 35464085

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In this study, we found that the asymmetric development of bilateral gonads of E18.5, ZW embryos was significantly improved after overexpression of Tle4z1 , and the gonadal development of ZZ embryos showed a trend of asymmetric development in the interference group, which indicated that Tle4z1 could play a role in the gonadal development of both sexes and made the sexual phenotype of chicken embryos develop to male.

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