This is highly significant assuming an additive model t = 5.2 (Student’s left-tailed t-distribution p = 2.51 x 10 −06 ), with no evidence for a dominant effect (dom = 0.12 ± 0.09) t = 1.25 (Student’s left-tailed t-distribution p = 0.18).
We identified a genome-wide significant association (p = 4.12 x 10 −07 , adjusted for multiple testing via permutations p = 0.027, see Methods ) on chromosome 15 (15:49–50 Mb; Fig 2 ), followed by two neighbouring haplotypes (15:46–47 Mb unadjusted p = 9.1 x 10 −6 ; 15:47–48 Mb unadjusted p = 1.43 x 10 −5 ) which, although also nominally significant, were not significant genome-wide after correction (15:46–47 Mb corrected p = 0.23; 15:47–48 Mb corrected p = 0.32).