Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer's Disease.

J Alzheimers Dis · 2022 · PMC9028616 · PMID 35068462

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0680

boldest claim

The sentences

marginally significantp = 0.06so close (0.05 < p ≤ 0.1)

3 a), there was a significant interaction between condition and genotype for 2 weeks (F(1,46) = 5.44, p = 0.02), while the effect in the 6-week group was marginally significant (F(1,42) = 4.829, p = 0.06).

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a trend toward significancep = 0.068so close (0.05 < p ≤ 0.1)

Further investigation found that although there was a trend toward significance in the dorsal cortex ( p = 0.068, etasq = 0.08) this result was driven by a significant effect in the septum (2 weeks: M = 0.60, SD = 0.57; 6 weeks: M = 4.04, SD = 2.79; p < 0.0001, etasq = 0.48).

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showed a trendno p-value reported

Given the findings that our mice showed a trend for a loss of function that is consistent with previous findings and thus a suitable model, we assessed for differences between sham and rTMS in full experiment groups to determine if stimulation may help boost such deficits.

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