Mechanistic Origin of Different Binding Affinities of SARS-CoV and SARS-CoV-2 Spike RBDs to Human ACE2.

These results indicate that, although D476G plays an overwhelming role in enhancing the ACE2-binding affinity, there is a clear trend in which the increased close contacts on the non-conserved RBD Co V2 interface residues considerably enhance the ACE2-binding affinity of RBD CoV2 .

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