Phospholipids alter activity and stability of mitochondrial membrane-bound ubiquitin ligase MARCH5.

Life Sci Alliance · 2022 · PMC9034062 · PMID 35459736

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showed a trendno p-value reported

Furthermore, MARCH5 showed a trend towards enhanced auto-ubiquitination in the presence of PA and PG.

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an increasing trendno p-value reported

In contrast, incubating MARCH5 in the presence of increasing PA concentration showed again an increasing trend towards increased auto-ubiquitination, especially in the 1:50 M ratio of protein to lipid ( Fig S5A–C and E ).

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