Barely Significant
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Copper nanoparticle anchored biguanidine-modified Zr-UiO-66 MOFs: a competent heterogeneous and reusable nanocatalyst in Buchwald-Hartwig and Ullmann type coupling reactions.

RSC Adv · 2021 · PMC9034177 · PMID 35480808

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quite significantno p-value reported
However, prior to general studies, optimization of the reaction conditions seemed quite significant and hence, a reaction between indole and iodobenzene was selected as a model and an array of screening experiments were conducted applying diverse conditions like catalyst load, solvent, base and temperature.

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