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Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts.

Aging (Albany NY) · 2022 · PMC9037271 · PMID 35378512

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Levels of Cdkn2a (p16 and p19) in P6 MEFs tended to be reduced by incubation with 30 ng/ml IGFBP5 from P2, but the difference did not reach statistical significance.

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