Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca<sup>2+</sup>-PPP3/calcineurin-TFEB axis.

Autophagy · 2022 · PMC9037459 · PMID 34338148

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Treatment of db/db mice with Ex4 showed a trend toward increased INS protein expression ( Figure 8A ), consistent with the improved glucose tolerance.

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