Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness.

We observed that compromised DNA repair in part explains diminished Treg proliferation in WT aged mice, as Tregs of Ercc1 −/Δ7 mice showed a trend toward reduced proliferation in response to anti-CD3 alone and significantly reduced proliferation in response to anti-CD3 with IL-2 ( Figures 5A,B ).

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