Rare coding variants in DNA damage repair genes associated with timing of natural menopause.

At RAD54L , conditional analysis suggested that the common GWAS variants rs12142240 (reported by ReproGen) and rs12073998 (the strongest common-variant association we found, which is in high linkage disequilibrium with rs12142240) were in high linkage disequilibrium with all of the other genome-wide significant associations at the locus, and rare missense rs28363218 remained nominally significant at p = 2.6 × 10 −3 , suggesting its independence ( Table S9 ).

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